Long-Term Outcomes of Anticoagulation Monotherapy Versus Combination Therapy in Atrial Fibrillation Patients with Complex Coronary Artery Disease

26 November 2025 : Database Analysis

Wei-Chieh Lee^{ABCDG 1,2*}, Wei-Ting Chang^{F 1,2}, Chon-Seng Hong^{B 2}, Chih-Hsien Lin^{B 2}, Chun-Yen Chiang

^{B 2}, Pei-Chieh Huang^{B 2}, Zhih-Cherng Chen^{BF 1,2}, Jhih-Yuan Shih^{B 1,2}, Hsiu-Yu Fang^{EF 3,4}

DOI: 10.12659/MSM.950655

Med Sci Monit 2025; 31:e950655

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Table 3 Univariate Cox regression analyses of predictors of revascularization more than 1 year after percutaneous coronary intervention.

Variables	Univariate analysis
Variables	HR	95% CI	P value
Age	0.993	0.939–1.050	0.801
Female	1.615	0.555–4.694	0.379
APT plus OAC	4.003	1.287–12.450	0.017
ACS	1.274	0.469–3.459	0.635
Hypertension	1.670	0.537–5.191	0.375
Diabetes mellitus	1.275	0.284–2.167	0.640
Prior stroke	0.770	0.174–3.411	0.731
CKD	0.642	0.146–2.830	0.559
Heart failure	1.920	0.720–5.120	0.192
Dyslipidemia	0.686	0.255–1.846	0.456
Prior MI	4.310	0.915–20.297	0.065
PAOD	1.036	0.234–4.594	0.962
Peptic ulcer	0.623	0.140–2.764	0.534
Persistent AF	0.661	0.245–1.781	0.413
LVEF	1.015	0.983–1.048	0.349
EF <40%	0.296	0.039–2.241	0.238
Left main disease	1.127	0.250–3.146	0.853
Chronic total occlusion	1.260	0.180–3.500	0.760
SYNTAX score >33	2.359	0.096–1.875	0.258
Number of stents >3	1.679	0.077–4.613	0.620
ACEI/ARB/Entresto	0.044	0–854.665	0.535
β-blocker	1.770	0.400–7.824	0.452
High-intensity statin	0.788	0.292–2.121	0.637
Long-term PPI	1.356	0.179–10.285	0.768
CHA2DS2-VA score	1.156	0.798–1.673	0.444
HAS-BLED score	1.142	0.630–2.068	0.662
Data are expressed as the median (interquartile range) or as number (percentage). APT – antiplatelet therapy; OAC – oral anticoagulant; ACS – acute coronary syndrome; CKD – chronic kidney disease; PAOD – peripheral artery occlusive disease; MI – myocardial infarction; AF – atrial fibrillation; LVEF – left ventricular ejection fraction; EF – ejection fraction; ACEI – angiotensin-converting enzyme inhibitor; ARB – angiotensin receptor blocker; PPI – proton pump inhibitor.

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