06 December 2025 : Clinical Research
Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study
Yudiao Liang CD 1, Heping Jiang BCE 1, Bo Liu AE 1, Jie Liao B 1, Yanping Feng B 1, Ruini He AF 1, Sha Zhang BF 1, Youguo Tan AG 1*DOI: 10.12659/MSM.950780
Med Sci Monit 2025; 31:e950780
Table 2 Task-evoked oxy-hemoglobin concentration changes (mean±SD) in 6 pre-defined prefrontal regions of interest (ROIs) during the verbal fluency task, compared between predominantly positive (PSZ) and predominantly negative (NSZ) symptom schizophrenia groups.
| PSZ | NSZ | P | |||
|---|---|---|---|---|---|
| n | % | n | % | ||
| IFG_L | −0.029 | 0.206 | −0.015 | 0.355 | 0.840 |
| MFG_L | 0.043 | 0.167 | 0.079 | 0.173 | 0.420 |
| SFG_L | 0.048 | 0.132 | 0.038 | 0.121 | 0.753 |
| SFG_R | 0.018 | 0.120 | 0.010 | 0.162 | 0.828 |
| MFG_R | 0.007 | 0.114 | 0.020 | 0.144 | 0.694 |
| IFG_R | 0.006 | 0.143 | 0.042 | 0.228 | 0.453 |
| PSZ – predominantly positive symptom schizophrenia; NSZ – predominantly negative symptom schizophrenia; IFG_L – left inferior frontal gyrus; MFG_L – left middle frontal gyrus; SFG_L – left superior frontal; SFG_R – right superior frontal gyrus; MFG_R – right middle frontal gyrus; IFG_R – right inferior frontal gyrus; ROI – region of interest; SD – standard deviation. | |||||