06 December 2025 : Clinical Research
Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study
Yudiao Liang CD 1, Heping Jiang BCE 1, Bo Liu AE 1, Jie Liao B 1, Yanping Feng B 1, Ruini He AF 1, Sha Zhang BF 1, Youguo Tan AG 1*DOI: 10.12659/MSM.950780
Med Sci Monit 2025; 31:e950780
Table 3 Significant between-group differences in oxy-haemoglobin activation at channels Ch21 and Ch51 (frontal pole, orbitofrontal cortex, and triangular Broca’s area) during the verbal fluency task in predominantly positive (PSZ) versus predominantly negative (NSZ) symptom schizophrenia.
| PSZ | NSZ | P | |||
|---|---|---|---|---|---|
| n | % | n | % | ||
| Ch21 | −0.1337 | 0.90785 | 0.5068 | 1.55065 | 0.047 |
| Ch51 | −0.0542 | 0.21716 | 0.0643 | 0.2134 | 0.038 |
| PSZ – predominantly positive symptom schizophrenia; NSZ – predominantly negative symptom schizophrenia; SD – standard deviation. | |||||