06 December 2025 : Clinical Research
Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study
Yudiao Liang CD 1, Heping Jiang BCE 1, Bo Liu AE 1, Jie Liao B 1, Yanping Feng B 1, Ruini He AF 1, Sha Zhang BF 1, Youguo Tan AG 1*DOI: 10.12659/MSM.950780
Med Sci Monit 2025; 31:e950780
Table 4 Pearson correlations (r) and coefficients of determination (R2) between activation levels at channels Ch51 and Ch21 and Brief Psychiatric Rating Scale (BPRS) factor scores across all schizophrenia patients. Asterisks denote statistical significance (* P<0.05).
| Total scores | Anxiety/depression | Lack of vitality | Thought disturbance | Activation | Hostility/suspicion | ||
|---|---|---|---|---|---|---|---|
| Ch51 | R | −0.025 | 0.058 | 0.175 | 0.124 | −0.292* | −0.115 |
| p | 0.846 | 0.656 | 0.177 | 0.341 | 0.022 | 0.378 | |
| R | 0.001 | 0.003 | 0.029 | 0.015 | 0.084 | 0.013 | |
| Ch21 | R | −0.096 | −0.096 | 0.133 | 0.074 | −0.163 | −0.178 |
| p | 0.460 | 0.464 | 0.307 | 0.571 | 0.208 | 0.171 | |
| R | 0.009 | 0.009 | 0.018 | 0.005 | 0.026 | 0.031 | |
| Ch – channel; * ** R – R square. | |||||||