02 December 2025 : Clinical Research
Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy
Jia Wang
ABCDEF 1, Xue-qin Bai ABCDEF 1, Meng Li BCDEF 2,3, Xing-jie Wang BCF 4, Shuo-wen Sun BCF 4, Lei Huang ABCDEFG 3,5, Xu Zhang ACDEF 6,7*, Xin Chen ACDEF 1,8
DOI: 10.12659/MSM.950838
Med Sci Monit 2025; 31:e950838
Table 2 Wilcoxon Rank-Sum Test results for differentially abundant oxylipins.
| Lipid code | Chemical name | FDR | -log10 P |
|---|---|---|---|
| AA_LOX_12-HETE | 12-Hydroxyeicosatetraenoic acid | 6.01×10 | 4.22 |
| AA_LOX_5-HETE | 5-Hydroxyeicosatetraenoic acid | 0.00044 | 3.36 |
| AA_LOX_9-HETE | 9-Hydroxyeicosatetraenoic acid | 0.0011 | 2.94 |
| AA_COX_PGE2 | Prostaglandin E2 | 0.0068 | 2.17 |
| AA_LOX_11-HETE | 11-Hydroxyeicosatetraenoic acid | 0.0068 | 2.17 |
| AA_LOX_15-oxo-ETE | 15-Oxo-eicosatetraenoic acid | 0.0068 | 2.17 |
| AA_LOX_15-HETE | 15-Hydroxyeicosatetraenoic acid | 0.019 | 1.73 |
| DHA_LOX_10-HDoHE | 10-Hydroxydocosahexaenoic acid | 0.021 | 1.68 |
| EPA_LOX_9-HEPE | 9-Hydroxyeicosapentaenoic acid | 0.021 | 1.68 |
| EPA_P450_18-HEPE | 18-Hydroxyeicosapentaenoic acid | 0.026 | 1.59 |
| EPA_LOX_12-HEPE | 12-Hydroxyeicosapentaenoic acid | 0.026 | 1.58 |
| AA_P450_16-HETE | 16-Hydroxyeicosatetraenoic acid | 0.026 | 1.58 |
| DHA_LOX_14-HDoHE | 14-Hydroxydocosahexaenoic acid | 0.028 | 1.56 |
| AA_LOX_6R-LXA4 | Lipoxin A4 | 0.028 | 1.56 |
| AA_COX_PGF2a | Prostaglandin F2α | 0.028 | 1.56 |
| DHA_LOX_11-HDoHE | 11-Hydroxy-docosahexaenoic acid | 0.028 | 1.56 |
| List of 16 oxylipins with FDR-adjusted | |||