18 October 2025 : Clinical Research
Clinical Outcomes and Prognostic Factors in Cerebral Abscess: Hyperglycemia as a Predictor of the Need for Prolonged Antibiotic Therapy
Joon O Park BCDEF 1,2, Seongwoo Lee BCDF 1, Jang Hun Kim ACDE 1, Dong-Hyuk Park BCDE 1, Shin-Hyuk Kang BCDEF 1, Kyung-Jae Park ADEFG 1*DOI: 10.12659/MSM.950987
Med Sci Monit 2025; 31:e950987
Table 5 Statistical analysis of treatment outcomes.
| Factors | Favorable outcome (GOS ≥4, N=87) | Unfavorable outcome (GOS <4, N=25) | P value | Multivariate analysis* | ||
|---|---|---|---|---|---|---|
| P value | Exp(B) | 95% CI | ||||
| Age (years, mean±SD) | 53.0±17.8 | 57.5±16.7 | 0.169 | NA | NA | NA |
| Male sex, n (%) | 72 (83%) | 18 (72%) | 0.233 | NA | NA | NA |
| Duration of symptoms (days, mean±SD) | 8.8±11.8 | 4.4±7.9 | 0.033 | 0.383 | 0.970 | 0.906–1.039 |
| Glasgow Coma Scale ≥13 | 79 (91%) | 11 (44%) | <0.001 | 0.002 | 7.056 | 2.045–24.348 |
| Presence of predisposing sources | 37 (43%) | 15 (60%) | 0.123 | NA | NA | NA |
| Known diabetes | 16 (18%) | 4 (16%) | 0.783 | NA | NA | NA |
| Immunocompromised | 5 (6%) | 5 (20%) | 0.028 | 0.225 | 2.568 | 0.559–11.784 |
| White blood cell count (/μL, mean±SD) | 11316±4261 | 11993±4985 | 0.502 | NA | NA | NA |
| Erythrocyte sedimentation rate (mm/h, mean±SD) | 31.5±22.9 | 45.2±45.6 | 0.157 | NA | NA | NA |
| C-reactive protein (mg/L, mean±SD) | 30.0±42.3 | 84.5±96.3 | 0.010 | 0.242 | 1.005 | 0.996–1.014 |
| Blood glucose (mg/dL, mean±SD) | 138.9±44.5 | 164.8±73.6 | 0.031 | 0.091 | 1.008 | 0.999–1.017 |
| Identification of microorganism on abscess culture | 41 (47%) | 15 (60%) | 0.257 | NA | NA | NA |
| Multiple operations | 11 (13%) | 2 (8%) | 0.729 | NA | NA | NA |
| Multiple abscesses | 11 (13%) | 5 (20%) | 0.354 | NA | NA | NA |
| Initial abscess volume (cm, mean±SD) | 18.5±14.2 | 21.1±13.2 | 0.401 | NA | NA | NA |
| Postoperative residual abscess volume (cm, mean±SD) | 6.7±6.7 | 7.8±7.6 | 0.520 | NA | NA | NA |
| * Variables with value CI – Confidence Interval; GOS – Glasgow Outcome Scale; NA – not available; SD – standard deviation. | ||||||