18 October 2025 : Clinical Research
Clinical Outcomes and Prognostic Factors in Cerebral Abscess: Hyperglycemia as a Predictor of the Need for Prolonged Antibiotic Therapy
Joon O Park BCDEF 1,2, Seongwoo Lee BCDF 1, Jang Hun Kim ACDE 1, Dong-Hyuk Park BCDE 1, Shin-Hyuk Kang BCDEF 1, Kyung-Jae Park ADEFG 1*DOI: 10.12659/MSM.950987
Med Sci Monit 2025; 31:e950987
Table 6 Statistical analysis of antibiotic treatment duration.
| Factors | Early responder (<6 weeks of antibiotics, N=54) | Delayed responder (≥6 weeks or longer of antibiotics, N=58) | P value | Multivariate analysis* | ||
|---|---|---|---|---|---|---|
| P value | Exp(B) | 95% CI | ||||
| Age (years, mean±SD) | 53.2±17.6 | 53.2±17.8 | 0.978 | NA | NA | NA |
| Male sex, n (%) | 43 (80%) | 47 (81%) | 0.852 | NA | NA | NA |
| Duration of symptoms (days, mean±SD) | 8.9±11.7 | 6.8±10.7 | 0.334 | NA | NA | NA |
| Glasgow Coma Scale ≥13 | 49 (91%) | 41 (71%) | 0.008 | 0.130 | 2.658 | 0.751–9.410 |
| Presence of predisposing factors | 24 (44%) | 28 (48%) | 0.685 | NA | NA | NA |
| Known diabetes mellitus | 8 (15%) | 12 (21%) | 0.417 | NA | NA | NA |
| Immunocompromised | 7 (13%) | 3 (5%) | 0.192 | NA | NA | NA |
| White blood cell count (/μL, mean±SD) | 10 288±2821 | 12 565±5299 | 0.005 | 0.209 | 1.000 | 1.000–1.000 |
| Erythrocyte sedimentation rate (mm/h, mean±SD) | 30.6±24.2 | 38.3±34.0 | 0.170 | NA | NA | NA |
| C-reactive protein (mg/L, mean±SD | 30.5±46.2 | 53.0±73.4 | 0.054 | 0.779 | 1.001 | 0.993–1.010 |
| Blood glucose (mg/dL, mean±SD) | 125.7±30.7 | 162.4±62.8 | <0.001 | 0.004 | 1.017 | 1.005–1.029 |
| Identification of pathogen on abscess culture | 25 (46%) | 31 (53%) | 0.449 | NA | NA | NA |
| Multiple operations | 4 (7%) | 9 (16%) | 0.242 | NA | NA | NA |
| Multiple abscesses | 10 (19%) | 6 (10%) | 0.217 | NA | NA | NA |
| Initial abscess volume (cm, mean±SD) | 18.5±15.7 | 19.6±12.3 | 0.668 | NA | NA | NA |
| Postoperative residual abscess volume (cm, mean±SD) | 6.4±7.6 | 7.5±6.2 | 0.426 | NA | NA | NA |
| * Variables with value CI – Confidence Interval; NA – not available; SD – standard deviation. | ||||||