14 December 2025 : Clinical Research
The Silent Face of Chronic Hepatitis B: Biopsy-Supported Fibrosis Detection and the Reliability of Non-Invasive Scores (FIB-4, APRI) in Inactive, Gray Zone, and Immune-Tolerant Cases
Mehmet Kasım Aydın
ABCDEFG 1*
DOI: 10.12659/MSM.951084
Med Sci Monit 2025; 31:e951084
Table 1 Descriptive characteristics of the study population (n=230).
| Characteristics | Mean±SD/n | Min–Max |
|---|---|---|
| Age | 44.4±12.2 | 18–73 |
| Sex | ||
| Male | 106 | 46.1 |
| Female | 124 | 53.9 |
| Treatment requirement | ||
| No | 144 | 62.6 |
| Yes | 86 | 37.4 |
| PT(sec) | 13.11±1.65 | 9.5–16.40 |
| GGT | 20.01±12.51 | 1.74–97.4 |
| INR | 1.04±0.11 | 0.80–1.91 |
| AST | 22.08±8.76 | 2–91.78 |
| ALT | 21.05±6.07 | 7.73–32 |
| PLT | 236.66±61.99 | 100–412 |
| HBsAG | 2998.75±573.73 | 72–4706 |
| HAI | 4.9±2.2 | 1–16 |
| Fibrosis Score | 2.1±0.89 | 0–5 |
| FIB-4 | 1.04±0.80 | 0.06–5.98 |
| APRI | 0.32±0.18 | 0.03–1.54 |
| PT – prothrombin time (seconds); GGT – gamma-glutamyl transferase INR – international normalized ratio AST – aspartate aminotransferase ALT – alanine aminotransferase PLT – platelet count HBsAg – hepatitis B surface antigen HAI – histological activity index APRI – Aspartate Aminotransferase-to-Platelet Ratio Index; FIB-4 – Fibrosis-4 Index. | ||