The Silent Face of Chronic Hepatitis B: Biopsy-Supported Fibrosis Detection and the Reliability of Non-Invasive Scores (FIB-4, APRI) in Inactive, Gray Zone, and Immune-Tolerant Cases

14 December 2025 : Clinical Research

Mehmet Kasım Aydın

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DOI: 10.12659/MSM.951084

Med Sci Monit 2025; 31:e951084

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Table 2 Comparison of FIB-4 and APRI scores according to fibrosis stage in the patients (n=230).

	Fibrosis score <3n=184	Fibrosis score ≥3n=46	P value
	Mean±SD	Mean±SD	P value
FIB-4	0.91±0.55	1.53±0.90	0.003
APRI	0.29±0.15	0.44±0.23	0.001
Based on -test, a value less than 0.05 was considered statistically significant. APRI – Aspartate Aminotransferase-to-Platelet Ratio Index; FIB-4 – Fibrosis-4 Index.

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