The Silent Face of Chronic Hepatitis B: Biopsy-Supported Fibrosis Detection and the Reliability of Non-Invasive Scores (FIB-4, APRI) in Inactive, Gray Zone, and Immune-Tolerant Cases

14 December 2025 : Clinical Research

Mehmet Kasım Aydın

^{ABCDEFG 1*}

DOI: 10.12659/MSM.951084

Med Sci Monit 2025; 31:e951084

Authors information Article notes Copyright and License information

Introduction Material and Methods Results Discussion Conclusions References

Related articles Order reprints Share article Share by email

View HTML version

Table 3 Cut-off values for FIB-4 and APRI in predicting significant fibrosis (F ≥3).

	AUC	Cut-off	SEN%	SPE%	P value	PPV%	NPV%
FIB-4	0.70	>1.06	70	75	0.001	76	87
APRI	0.68	>0.38	65	86	0.001	66	87
AUC – area under the curve; APRI – Aspartate Aminotransferase-to-Platelet Ratio Index; FIB-4 – Fibrosis-4 Index; NPV – negative predictive value; PPV – positive predictive value; SEN – sensitivity; SPE – specificity.

Back to the Article