25 January 2026 : Clinical Research
Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial
Zhong Zhang BCE 1, Wei Jiang ABF 1, Longjiao Zheng BCF 1, Zhiyang Yu ACDE 1*DOI: 10.12659/MSM.951195
Med Sci Monit 2026; 32:e951195
Table 2 Consumption of anesthetics and sedation-related time.
| Variable | Propofol (n=64) | Ciprofol (n=64) | Estimated difference (95% CI) | χ2/t | P |
|---|---|---|---|---|---|
| Nalbuphine dose (mg) | 9.4±1.7 | 9.8±1.6 | −0.37 (−0.97 to 0.23) | 0.397 | 0.225 |
| Sedative-agent dose (mg) | |||||
| Induction dose | 125.9±23.5 | 26.1±4.4 | |||
| Maintainence dose | 56.6±10.6 | 19.6±3.3 | |||
| Total dose | 182.6±34.1 | 45.8±7.8 | |||
| Time (min) | |||||
| Induction | 51.4±4.9 | 48.9±3.6 | 2.54 (1.03 to 4.06) | 3.328 | 0.001 |
| Operation | 20.6±2.9 | 20.1±2.6 | 0.46 (−0.52 to 1.46) | 0.935 | 0.352 |
| Recover | 7.1±1.1 | 7.1±1.2 | 0.01 (−0.40 to 0.43) | 0.073 | 0.942 |