25 January 2026 : Clinical Research
Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial
Zhong Zhang BCE 1, Wei Jiang ABF 1, Longjiao Zheng BCF 1, Zhiyang Yu ACDE 1*DOI: 10.12659/MSM.951195
Med Sci Monit 2026; 32:e951195
Table 4 Hemodynamics between the 2 groups.
| Variable | Propofol (n=64) | Ciprofol (n=64) | Estimated difference (95% CI) | t | P | |
|---|---|---|---|---|---|---|
| SBP (mmHg) | T1 | 134.8±12.7 | 132.9±11.9 | 1.87 (−2.46 to 6.21) | 0.856 | 0.394 |
| T2 | 113.0±13.1 | 118.1±12.8 | −5.10 (−9.64 to −0.57) | 2.230 | 0.028 | |
| T3 | 117.3±9.4 | 122.4±9.9 | −5.12 (−8.52 to −1.72) | 2.980 | 0.003 | |
| T4 | 124.2±6.2 | 125.5±8.2 | −1.28 (−3.83 to 1.27) | 0.993 | 0.323 | |
| T5 | 135.1±8.2 | 134.3±7.2 | 0.79 (−1.91 to 3.51) | 0.581 | 0.562 | |
| DBP (mmHg) | T1 | 77.2±9.5 | 77.2±9.8 | 0.07 (−3.31 to 3.47) | 0.046 | 0.964 |
| T2 | 66.2±6.4 | 69.4±7.0 | −3.20 (−5.56 to −0.84) | 2.683 | 0.008 | |
| T3 | 69.7±6.3 | 72.6±7.3 | −2.89 (−5.29 to −0.48) | 2.379 | 0.019 | |
| T4 | 72.6±5.4 | 74.2±6.7 | −1.59 (−3.74 to 0.56) | 1.463 | 0.146 | |
| T5 | 77.3±5.2 | 78.4±5.8 | −1.04 (−2.98 to 0.88) | 1.071 | 0.286 | |
| MAP (mmHg) | T1 | 96.4±9.9 | 95.7±10.0 | 0.67 (−2.81 to 4.17) | 0.383 | 0.702 |
| T2 | 81.3±8.9 | 85.6±8.4 | −4.35 (−7.39 to −1.31) | 2.833 | 0.005 | |
| T3 | 85.6±6.5 | 89.2±7.4 | −3.63 (−6.09 to −1.17) | 2.930 | 0.004 | |
| T4 | 89.8±3.9 | 91.3±6.3 | −1.48 (−3.32 to 0.34) | 1.604 | 0.111 | |
| T5 | 96.6±4.5 | 97.0±4.8 | −0.43 (−2.07 to 1.21) | 0.521 | 0.603 | |
| HR (bpm) | T1 | 82.1±8.5 | 81.9±9.3 | 0.17 (−2.96 to 3.31) | 0.108 | 0.914 |
| T2 | 73.2±9.1 | 73.0±8.0 | 0.20 (−2.81 to 3.21) | 0.133 | 0.894 | |
| T3 | 74.3±7.1 | 73.3±5.6 | 1.03 (−1.22 to 3.28) | 0.904 | 0.368 | |
| T4 | 79.0±6.4 | 80.6±6.4 | −1.54 (−3.80 to 0.70) | 1.359 | 0.177 | |
| T5 | 83.0±5.4 | 83.3±6.4 | −0.26 (−2.34 to 1.81) | 0.252 | 0.801 | |
| Systolic pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded at 5 time points during this study: T1 – before anesthesia induction, T2 – at the time of gastroscopy reaching the throat, T3 – colonoscopy to the ileocecal region, T4 – at the end of the operation, T5 – before leaving the recovery room. | ||||||