23 January 2026 : Clinical Research
Predicting the Effectiveness of 2 Chemotherapy Regimens Applied to Breast Cancer Patients by Nutritional and Inflammatory Status
Mehmet Salim Demir
ABCDEFG 1*, Gözde Ağdaş BCFG 1
DOI: 10.12659/MSM.951548
Med Sci Monit 2026; 32:e951548
Table 1 Baseline characteristics of neoadjuvant chemotherapy protocols.
| Variables | ddAC-THP (n: 72) | TCHP (n: 40) | P value |
|---|---|---|---|
| Age (years) | 47.35±10.83 | 50.03±11.2 | 0.156 |
| BMI (kg/m) | 29.6±5.36 | 28.09±4.61 | 0.258 |
| BSA (cm) | 173±14.2 | 167±12.3 | 0.836 |
| CA15-3 (U/mL) | 30.3±19.2 | 28±14.1 | 0.422 |
| CA125 (U/mL) | 24±16.4 | 26±11.7 | 0.126 |
| Hemoglobin (g/dL) | 13.1±1.4 | 13±1.2 | 0.765 |
| Glucose (mg/dL) | 119±44.4 | 123±47.6 | 0.795 |
| Albumin (g/L) | 42.8±3.2 | 43.2±3.1 | 0.506 |
| Cholesterol (mg/dL) | 167±8.7 | 168±7.9 | 0.772 |
| CRP (mg/L) | 6.2±5.1 | 4.8±3.2 | 0.064 |
| WBC (/mm) | 6309±1435 | 6326±1458 | 0.961 |
| Neutrophil (/mm) | 3759±1268 | 3867±1240 | 0.607 |
| Lymphocyte (/mm) | 1375±560 | 1392±613 | 0.887 |
| Platelet count (×10/μL) | 235±66 | 255±77 | 0.218 |
| Vitamin D (ng/mL) | 13.4±7.4 | 15.5±8.2 | 0.208 |
| Premenopausal status | 31 (43.1%) | 13 (32.5%) | 0.071 |
| Smoking | 7 (9.7%) | 7 (17.5%) | 0.371 |
| Chronic disease | 19 (26.4%) | 15 (37.5%) | 0.312 |
| Hypertension | 13 (18.1%) | 12 (30%) | 0.223 |
| Diabetes mellitus | 10 (13.9%) | 8 (20%) | 0.565 |
| CAD | 7 (9.7%) | 4 (10%) | 0.924 |
| COPD | 6 (8.3%) | 2 (5%) | 0.709 |
| CHF | 0 (0%) | 1 (2.5%) | 0.357 |
| BMI – body mass index; BSA – body surface area; CA15-3 – cancer antigen 15-3; CA125 – cancer antigen 125; CRP – C-reactive protein; WBC – white blood cell count; CAD – coronary artery disease; COPD – chronic obstructive pulmonary disease; CHF – congestive heart failure; ddAC-THP – dose-dense adriamycin and cyclophosphamide followed by taxane, trastuzumab, and pertuzumab; TCHP – docetaxel, carboplatin, trastuzumab, and pertuzumab. Continuous variables were presented as mean±standard deviation and compared using the independent test. Categorical variables were expressed as numbers and percentages [n (%)] and analyzed using the chi-square test or Fisher’s exact test when appropriate. A value of less than 0.05 was considered statistically significant. | |||