Predictors of In-Hospital Mortality in Patients With Type 2 Diabetes Complicated by Isolated Hyperosmolar Hyperglycemic Syndrome

09 April 2026 : Clinical Research

Yaping Sun

^{BCDEF 1,2}, Xinyue Bian

^{BCE 1,2}, Li Li

^{BCD 2}, Lihong Yuan

^{BF 3}, Wei Zhang

^{BC 1,2}, Wanjun Yin

^{ACDF 4*}, Liwu Xu

^{ACDEG 2}

DOI: 10.12659/MSM.951636

Med Sci Monit 2026; 32:e951636

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Table 3 Logistic regression analysis of risk factors for in-hospital mortality in patients with HHS.

Variable	Univariate model			Multivariate model
Variable	OR	95% CI	P	OR	95% CI	P
CCI Score	2.503	1.621–3.866	<0.001	2,679	1.257–5.710	0.011
Use of LMWH	0.193	0.075–0.497	0.001	0.033	0.004–0.302	0.003
CRP (mg/L)	1.005	1.000–1.011	0.048	1.003	0.991–1.016	0.638
D-dimer (mg/L)	1.049	1.008–1.092	0.019	1.058	1.001–1.118	0.047
Cr (μmol/L)	1.007	1.003–1.011	0.001	1.005	0.998–1.013	0.167
FDP (mg/L)	1.103	0.999–1.026	0.066
BUN (mmol/L)	1.117	1.064–1.172	<0.001	1.103	1.021–1.193	0.013
Cys-C (mg/L)	3.003	1.940–4.646	<0.001	1.745	1.031–2.953	0.038
HHS – hyperosmolar hyperglycemic syndrome; CCI – Charlson Comorbidity Index; CRP – C-reactive protein; Cr – creatinine; BUN – blood urea nitrogen; FDP – fibrin degradation products; Cys-C – cystatin C; LMWH – low molecular weight heparin.

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