Predictive Value of Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) and Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) for Biochemical Recurrence After Radical Prostatectomy

29 December 2025 : Clinical Research

Hui Wang^{ABCDEFG 1*}, Chenxi Huang^{BDE 2}

DOI: 10.12659/MSM.951769

Med Sci Monit 2025; 31:e951769

Authors information Article notes Copyright and License information

Introduction Material and Methods Results Discussion Conclusions Data Availability Statement References

Related articles Order reprints Share article Share by email

View HTML version

Table 2 Univariate and multivariate Cox regression analysis of factors associated with postoperative BCR in PCa patients.

Variable	Univariable		Multivariable
Variable	HR (95% CI)	P	HR (95% CI)	P
Age (years)	1.024 (0.977–1.073)	0.317	/	/
BMI (kg/m)	1.070 (0.900–1272)	0.441	/	/
Preoperative PSA (≥20=1, <20=0)	2.053 (1.186–3.554)	0.010	1.886 (1.047–3.396)	0.034
Gleason Score (≥8=1, <8=0)	1.871 (1.127–3.109)	0.016	0.971 (0.565–1.666)	0.914
Pathologic T Stage (T3–4=1, T2=0)	2.014 (1.218–3.328)	0.006	1.762 (1.044–2.974)	0.034
Seminal Vesicle Invasion (Yes=1, No=0)	1.880 (1.137–3.106)	0.014	1.272 (0.728–2.222)	0.399
Positive Surgical Margins (Yes=1, No=0)	2.499 (1.429–4.370)	0.001	1.943 (1.084–3.482)	0.026
NLR	2.070 (1.767–2.424)	<0.001	1.348 (1.040–1.747)	0.024
suPAR (ng/mL)	5.190 (3.663–7.354)	<0.001	3.451 (2.186–5.448)	<0.001
Variables with P

Back to the Article