Predictive Value of Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) and Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) for Biochemical Recurrence After Radical Prostatectomy

29 December 2025 : Clinical Research

Hui Wang^{ABCDEFG 1*}, Chenxi Huang^{BDE 2}

DOI: 10.12659/MSM.951769

Med Sci Monit 2025; 31:e951769

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Table 3 Comparison of the predictive value of NLR, suPAR alone and in combination for postoperative BCR in PCa patients.

Indicator	AUC	95% CI	Cut-off value	Sensitivity (%)	Specificity (%)
NLR	0.873	0.826~0.919	2.350	90.32	67.21
suPAR	0.881	0.829~0.934	2.750	83.87	80.33
Combination	0.943	0.911~0.975	0.350	85.48	92.35
NLR~suPAR	=0.802
NLR~combination	<0.001
suPAR~combination	=0.004
Pairwise comparisons of the areas under the ROC curves (AUCs) were performed using DeLong’s test in MedCalc software ().

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