Baseline Tumor Biology Predicts Survival After Recurrence in Gastric Cancer: Impact of LVI, PNI, and HER2 Status

09 January 2026 : Clinical Research

Gözde Ağdaş

^{ABCDE 1*}, Mehmet Salim Demir

^{AF 1}

DOI: 10.12659/MSM.951829

Med Sci Monit 2026; 32:e951829

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Table 5 Univariate and multivariate Cox regression analyses for overall survival.

Overall survival	Univariate model			Multivariate model
Overall survival	HR	95% CI	P	HR	95% CI	P
Age	0.991	0.961–1.022	0.579
Sex	1.187	0.689–2.043	0.537
HER2 IHC	0.879	0.728–1.062	0.183
Lauren	0.847	0.459–1.564	0.597
Grade	0.959	0.619–1.485	0.851
Neoadjuvant CT	1.062	0.600–1.881	0.837
Surgery type	1.542	0.659–3.610	0.318
Ptnm	2.952	1.558–5.594
cT	2.047	1.480–2.830
cN	0.893	0.501–1.592	0.701
Ctnm	2.438	1.641–3.621		1.910	1.254–2.908
LND	0.996	0.536–1.852	0.991
Retrived LNs	1.009	0.9901.029	0.338
Metastatic LNs	1.023	0.9891.058	0.183
LVI	2.664	1.392–5.100		3.386	1.595–7.190
PNI	2.557	1.356–4.821
Adjuvant CT	0.385	0.224–0.663
First-line CT	0.407	0.209–0.791		0.224	0.101–0.498
Second-line CT	1.002	0.595–1.686	0.994
Third-line CT	0.894	0.437–1.826	0.758
Adjuvant CRT	0.500	0.282–0.887		0.440	0.224–0.865
Recurrence site	1.031	0.903–1.177	0.651
HR – hazard ratio; CI – confidence interval; P – P value; IHC – immunohistochemistry; CT – chemotherapy; CRT – chemoradiotherapy; LVI – lymphovascular invasion; PNI – perineural invasion; LND – lymph node dissection; LNs – lymph nodes; OS – overall survival.

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