Baseline Tumor Biology Predicts Survival After Recurrence in Gastric Cancer: Impact of LVI, PNI, and HER2 Status

09 January 2026 : Clinical Research

Gözde Ağdaş

^{ABCDE 1*}, Mehmet Salim Demir

^{AF 1}

DOI: 10.12659/MSM.951829

Med Sci Monit 2026; 32:e951829

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Table 6 Univariate and multivariate Cox regression analyses for disease-free survival.

Disease-free survival	Univariate model			Multivariate model
Disease-free survival	HR	95% CI	P	HR	95% CI	P
Age	0.988	0.957–1.019	0.439
Sex	1.333	0.816–2.177	0.252
HER2 IHC	0.832	0.693–0.998		0.781	0.641–0.953
Lauren	0.805	0.456–1.421	0.455
Grade	0.938	0.627–1.402	0.754
Neoadjuvant CT	1.191	0.717–1.977	0.500
Surgery type	0.972	0.458–2.061	0.940
Ptnm	1.878	1.154–3.058
cT	1.184	0.924–1.516	0.182
cN	1.065	0.620–1.830	0.819
Ctnm	1.455	1.052–2.011
LND	0.640	0.357–1.148	0.135
Retrived LNs	0.994	0.977–1.012	0.510
Metastatic LNs	0.995	0.966–1.025	0.723
LVI	2.110	1.166–3.818
PNI	1.736	1.003–3.003		1.909	1.055–3.455
Adjuvant CT	0.674	0.398–1.141	0.142
First-line CT	0.175	0.082–0.373		0.184	0.082–0.414
Second-line CT	0.555	0.340–0.906
Third-line CT	0.473	0.239–0.938	0.032
Adjuvant CRT	1.112	0.671–1.843	0.681
Recurrence site	1.018	0.897–1.155	0.785
DFS – disease-free survival; HR – hazard ratio; CI – confidence interval; p – p-value; IHC – immunohistochemistry; CT – chemotherapy; CRT – chemoradiotherapy; LVI – lymphovascular invasion; PNI – perineural invasion; LND – lymph node dissection; LNs – lymph nodes; cTNM – clinical tumor node metastasis stage; pTNM – pathological tumor node metastasis stage.

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