01 May 2026 : Laboratory Research
Evaluating Pharmacokinetics and Toxicity of Potential Therapeutics Against Enterococcus faecalis in Endodontic Pathologies
Nezar Boreak
ACDEFG 1*
DOI: 10.12659/MSM.951972
Med Sci Monit 2026; 32:e951972
Table 3 Toxicity of compounds 1 to 5.
| Ligand | Compound 1 | Compound 2 | Compound 3 | Compound 4 | Compound 5 |
|---|---|---|---|---|---|
| hERG blockers | −−− | −−− | −−− | −−− | −−− |
| H-HT | −−− | −− | −− | −− | −−− |
| DILI | −−− | −− | −− | − | −−− |
| AMES toxicity | −−− | −−− | −−− | −−− | −−− |
| Rat oral acute toxicity | −−− | −−− | −−− | −−− | −−− |
| FDAMDD | −−− | −−− | −− | −−− | −−− |
| Skin sensitization | ++ | + | − | ++ | +++ |
| Carcinogenicity | −−− | −−− | −−− | −− | −−− |
| Eye corrosion | +++ | +++ | +++ | +++ | +++ |
| Eye irritation | +++ | ++ | ++ | +++ | +++ |
| Respiratory toxicity | −− | −−− | −−− | + | −−− |
| For the classification endpoints, the prediction probability values are transformed into 6 symbols: 0–0.1(−−−), 0.1–0.3(−−), 0.3–0.5(−), 0.5–0.7(+), 0.7–0.9(++), and 0.9–1.0(+++). Compound 1: 2-hydroxyethyl methacrylate; compound 2: dimethyl adipate; compound 3: dimethyl glutarate; compound 4: dimethyl succinate; and compound 5: ethylene glycol dimethyl acrylate. hERG – human ether-a-go-go related gene; H-HT – human hepatotoxicity; DILI – drug-induced liver injury; FDAMDD – Food and Drug Administration maximum recommended daily dose. | |||||