Long-Term Endothelial Outcomes and Dislocation Risks in Small Versus Large Grafts for Descemet’s Stripping Endothelial Keratoplasty

25 April 2026 : Clinical Research

Yingxin Chen^{ABEG 1*}, Jiaxin Xiao^{ABCDEF 1}, Ruiyao Gao^{BCD 1}, Zhida You^{BCD 1}, Yanhong Ba^{B 1}

DOI: 10.12659/MSM.952103

Med Sci Monit 2026; 32:e952103

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Table 2 Postoperative observation indicators in the small-graft and large-graft groups of patients.

	Small-graft group (n=28)	Large-graft group (n=34)	P-value
ECD (cells/mm, mean±SD) (ECL%)
1 month postoperatively	1939.46±211.909 (−)	1845.79±258.376 (−)	0.129
3 months postoperatively	1878.29±213.250 (3.02±0.92%)	1781.62±263.923 (3.20±1.30%)	0.206
6 months postoperatively	1808.96±215.396 (6.82±1.15%)	1709.24±264.762 (7.59±2.07%)	0.072
12 months postoperatively	1478.57±274.711 (24.34±7.20%)	1489.21±332.051 (20.07±8.17%)	0.035^*
BCVA (logMAR, mean±SD)
1 month postoperatively	1.454±0.616	1.279±0.480	0.215
3 months postoperatively	1.129±0.489	0.948±0.385	0.107
6 months postoperatively	0.644±0.264	0.601±0.274	0.534
12 months postoperatively	0.540±0.260	0.489±0.268	0.452
Graft transparency at 12 months postoperatively (n, %)			0.595
Grade 0	27 (96.43%)	31 (91.18%)
Grade 1	1 (3.57%)	2 (5.88%)
Grade 2	0	1 (2.94%)
Complications (n, %)
Graft dislocation	3 (10.71%)	11 (32.35%)	0.043^*
Secondary glaucoma	6 (21.43%)	10 (29.41%)	0.475
Early (postoperative time ≤2 weeks)	2 (7.14%)	4 (11.76%)
Late (postoperative time >2 weeks)	4 (14.29%)	6 (17.65%)
Graft rejection	2 (7.14%)	4 (11.76%)	0.540
ECD – endothelial cell density; ECL – endothelial cell loss; SD – standard deviation; BCVA – best-corrected visual acuity. ^*

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