Phospho-Histone H3 as a Tool for Improved Mitotic Counting and Risk Assessment in Gastrointestinal Stromal Tumors: A Study of 241 Cases

15 April 2026 : Clinical Research

Xu Liu

^{ADE 1,2}, Jiao Liu^{BC 3}, Yahui Cui^{CF 4}, Hanhan Lei^{CD 1,2}, Yuchang Hu^{DG 1,2}, Yufei Liu^{DG 1,2*}

DOI: 10.12659/MSM.952182

Med Sci Monit 2026; 32:e952182

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Table 2 Correlation between MC-PHH3 and MC-HE in GIST with different RS.

RS	MC-PHH3	MC-HE	r	P value
Very low	2.00 (2.00, 3.00)	1.00 (0.00, 3.00)	0.686	<0.01
Low	3.00 (2.00, 4.00)	3.00 (2.00, 3.00)	0.644	<0.01
Medium	4.00 (3.00, 4.25)	3.00 (3.00, 4.00)	0.733	<0.01
High	12.50 (4.00, 20.25)	8.00 (3.00, 15.00)	0.927	<0.01
Total	4.00 (2.50, 8.00)	3.00 (2.00, 5.00)	0.879	<0.01
MC-PHH3 – mitotic count on phospho-histone H3; MC-HE – mitotic count on hematoxylin-eosin; GIST – gastrointestinal stromal tumor; RS – risk stratification.

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