Phospho-Histone H3 as a Tool for Improved Mitotic Counting and Risk Assessment in Gastrointestinal Stromal Tumors: A Study of 241 Cases

15 April 2026 : Clinical Research

Xu Liu

^{ADE 1,2}, Jiao Liu^{BC 3}, Yahui Cui^{CF 4}, Hanhan Lei^{CD 1,2}, Yuchang Hu^{DG 1,2}, Yufei Liu^{DG 1,2*}

DOI: 10.12659/MSM.952182

Med Sci Monit 2026; 32:e952182

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Table 4 Pairwise inter-observer variability results of mitotic counts using HE and PHH3.

Characteristic	Correlation	95% CI	P value
HE
Intra-class	0.648	0.534–0.748
Observer 1/Observer 2	0.677	0.524–0.787	<0.01
Observer 1/Observer 3	0.463	0.254–0.631	<0.01
Observer 2/Observer 3	0.623	0.453–0.749	<0.01
PHH3
Intra-class	0.710	0.608–0.795
Observer 1/Observer 2	0.804	0.702–0.875	<0.01
Observer 1/Observer 3	0.639	0.474–0.761	<0.01
Observer 2/Observer 3	0.648	0.486–0.767	<0.01
HE – hematoxylin-eosin; PHH3 – phospho-histone H3; CI – confidence interval.

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