Phospho-Histone H3 as a Tool for Improved Mitotic Counting and Risk Assessment in Gastrointestinal Stromal Tumors: A Study of 241 Cases

15 April 2026 : Clinical Research

Xu Liu

^{ADE 1,2}, Jiao Liu^{BC 3}, Yahui Cui^{CF 4}, Hanhan Lei^{CD 1,2}, Yuchang Hu^{DG 1,2}, Yufei Liu^{DG 1,2*}

DOI: 10.12659/MSM.952182

Med Sci Monit 2026; 32:e952182

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Table 5 Wilcoxon signed-rank test results of mitotic counts time with HE and PHH3.

Case count	Mean rank	Sum of ranks
PHH3 counting time - HE counting time	Negative ranks	163^a	146.14	23820.5
	Positive ranks	77^b	66.23	5099.5
	Ties	1^c
	Total	241
^a PHH3 counting time ^b PHH3 counting time >HE counting time; ^c PHH3 counting time=HE counting time. HE – hematoxylin-eosin; PHH3 – phospho-histone H3. ^a Wilcoxon signed-rank test; ^b Based on positive ranks.
Test statisticsa
Z	−8.694^b
Asymptotic significance (2-tailed)	<0.01
^a PHH3 counting time ^b PHH3 counting time >HE counting time; ^c PHH3 counting time=HE counting time. HE – hematoxylin-eosin; PHH3 – phospho-histone H3. ^a Wilcoxon signed-rank test; ^b Based on positive ranks.

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