15 July 2026 : Clinical Research
Effect of Dexmedetomidine Hydrochloride Nasal Spray on Anxiety and Sleep in Patients Undergoing Gynecological Laparoscopic Surgery
Lin Zhao ABC 1, Xiaotian Zhang BDG 2, Xiaoxiao Li AB 3, Yipeng He AB 1, Zhouquan Wu AF 1, Liang Zhu ABCDEG 1*DOI: 10.12659/MSM.952465
Med Sci Monit 2026; 32:e952465
Table 3 Anxiety score, sleep score, PACU stay time and discharge time of patients in the 2 groups.
| Control group | DEX group | Pb | ||
|---|---|---|---|---|
| PACU stay time, median (IQR), min | 26 (8) | 26 (8) | 0.802 | |
| Discharge time, median (IQR), min | 5 (1) | 5 (0) | <0.001 | |
| Anxiety score | T (30 min before entering the room) median (IQR) | 6 (7) | 6 (6) | 0.684 |
| T (before anesthesia) median (IQR) | 2 (2) | 2 (2) | 0.395 | |
| Sleep scoring | T (1 week before surgery) median (IQR) | 0 (2) | 1 (2) | 0.192 |
| T (day of surgery) median (IQR) | 7 (7) | 6 (10) | 0.771 | |
| T (first postoperative day) median (IQR) | 3 (2) | 2 (3) | 0.262 | |
| T (1 month after surgery) median (IQR) | 1 (2) | 0 (2) | 0.374 | |
| Sleep quality at T was not reduced compared with T (n=yes,%) | 2, 5% | 10, 25% | 0.012 | |
| Complications | T hypotension, slow heart rate (<50 times/min) (n,%) | 0 | 0 | 0.788 |
| Abbreviations: IQR, interquartile range. PACU, postanesthesia care unit. Note: is the comparison between the 2 groups, and | ||||