15 June 2026 : Clinical Research
Impact of Frailty Syndrome on Early and Midterm Adverse Events in Patients With Acute Coronary Syndrome
Radosław Wontor AEF 1, Maria Łoboz-Rudnicka
BDEF 1,2*, Bogusława Ołpińska B 1,2, Krzysztof D. Dudek C 3, Magdalena Lisiak B 4,5, Tomasz Bańkowski C 1, Rafał Wyderka D 1,2, Barbara Brzezińska B 1, Krystyna Łoboz-Grudzień AD 1, Joanna Jaroch AD 1,2
DOI: 10.12659/MSM.952737
Med Sci Monit 2026; 32:e952737
Table 3 Predictors of in-hospital and midterm (at 6-month follow-up) adverse events in the study population.
| Predictors of in-hospital complications | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| b | P | OR [95% CI] | beta | P | OR [95% CI] | |
| Age, years | 0.03 | 0.06 | 1.03 [1.00–1.07] | −0.02 | 0.36 | 0.98 [0.94–1.02] |
| Female sex | 0.10 | 0.75 | 1.20 [0.62–1.95] | – | – | – |
| ≤ | ||||||
| Interventional treatment | −0.11 | 0.76 | 0.90 [0.43–1.85] | – | – | – |
| Chronic kidney disease | −0.15 | 0.67 | 0.86 [0.44–1.71] | – | – | – |
| Smoking | −0.34 | 0.34 | 0.72 [0.36–1.43] | – | – | – |
| Arterial hypertension | 0.44 | 0.17 | 1.55 [0.82–2.92] | 0.03 | 0.94 | 1.03 [0.52–2.04] |
| Diabetes mellitus | 0.02 | 0.95 | 1.02 [0.55–1.88] | – | – | – |
| COPD | −0.52 | 0.31 | 0.60 [0.22–1.60] | – | – | – |
| Prior myocardial infarction | 0.04 | 0.91 | 1.04 [0.51–2.13] | – | – | – |
| Prior stroke | 0.57 | 0.25 | 1.77 [0.67–4.71] | 0.10 | 0.85 | 1.11 [0.37–3.28] |
| Oral anticoagulation | 0.08 | 0.86 | 1.09 [0.44–2.69] | – | – | – |
| ≥ | ||||||
| Age, years | 0.03 | 0.002 | 1.09 [1.03–1.15] | 0.056 | 0.08 | 1.06 [0.99–1.13] |
| Male sex | 0.13 | 0.80 | 1.12 [0.47–2.67] | – | – | – |
| ≤1 | ||||||
| Interventional treatment | −0.46 | 0.37 | 0.63 [0.23–1.73] | – | – | – |
| Chronic kidney disease | −0.04 | 0.94 | 0.96 [0.34–2.74] | – | – | – |
| Smoking | −0.69 | 0.29 | 0.50 [0.14–1.78] | – | – | – |
| Arterial hypertension | 0.15 | 0.77 | 1.16 [0.44–3.10] | – | – | – |
| Diabetes mellitus | −0.05 | 0.92 | 0.95 [0.37–2.43] | – | – | – |
| COPD | −0.12 | 0.88 | 0.89 [0.19–4.12] | – | – | – |
| Prior myocardial infarction | 0.42 | 0.42 | 1.52 [0.56–4.13] | – | – | – |
| Prior stroke | 0.74 | 0.23 | 2.09 [0.63–6.93] | – | – | – |
| Oral anticoagulation | −0.31 | 0.69 | 0.73 [0.16–3.36] | – | – | – |
| ≥2 | ||||||
| LVEF – left ventricular ejection fraction; TFI – Tilburg Frailty Indicator; COPD – chronic obstructive pulmonary disease. 1 Wide confidence interval reflects the high variability of LVEF measurements within the study group. 2 Wide confidence interval indicates limited predictive strength of TFI ≥8 score for MACCEs at 6 months. | ||||||