Discontinuation of Oral Anticoagulation After Successful Atrial Fibrillation Ablation – Are We Ready to Change Clinical Practice in 2026?

08 May 2026 : Review article

Karol Momot

^{ABCDEFG 1,2}, Stanisław Surma

^{ABEF 3}, Kamil Krauz

^{DEF 1,4*}, Michał Pruc

^{BEF 5}, Łukasz Szarpak

^{DEF 5,6}, Dariusz Rodkiewicz

^{EF 2}, Małgorzata Buksińska-Lisik

^{EF 2}, Artur Mamcarz

^{AE 2}

DOI: 10.12659/MSM.952757

Med Sci Monit 2026; 32:e952757

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Introduction Evidence Prior to Randomized Controlled Trials Data From Prospective Randomized Controlled Trials Discussion Conclusions References

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Table 2 Comparison of selected baseline characteristics between study groups.

	OCEAN		ALONE-AF
	Interventionn=643Aspirin	Controln=641Rivaroxaban	Interventionn=417Discontinued	Controln=423Continued
Age, years (mean±SD)	66.3±7.6	66.3±7.1	63±8	65±8
Male sex, %	71.4	71.5	77.0	73.3
Paroxysmal AF, %	65.5	67.2	66.2	69.0
CHADS-VASc score (mean±SD or median [IQR])	2.2±1.1	2.2±1.1	2 (1–3)	2 (1–3)
HAS-BLED (mean±SD or median [IQR])	1.3±0.8	1.4±0.9	2 (1–3)	2 (1–3)
Hypertension, %	67.5	69.0	70.3	68.8
Diabetes mellitus, %	12.0	15.0	16.3	21.3
Prior stroke or TIA, %	7.7	4.4	5.5	5.7
BMI, kg/m	Not reported	Not reported	25.3 (23.6–27.7)	25.0 (23.1–27.1)
LA diameter, mm (mean±SD or median [IQR])	40.4±19.2	40.7±16.0	40 (37–43)	40 (37–44)
LVEF, % (mean±SD or median [IQR])	61.5±7.3	61.8±7.1	61 (57–66)	62 (57–66)
AF – atrial fibrillation; BMI – body mass index; IQR – interquartile range; LA – left atrium; LVEF – left ventricular ejection fraction; SD – standard deviation; TIA – transient ischemic attack.

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