26 June 2026 : Meta-Analysis
Association Between Polymorphisms of 4 Common Genes and High Myopia Risk: A Comprehensive Analysis
Qianqian Yu BC 1*, Chao Sun DE 1, Tianhua Xie FG 1, Ningzhi Wangyang DE 1, Jun Shao BE 1, Yong Yao DF 1DOI: 10.12659/MSM.952771
Med Sci Monit 2026; 32:e952771
Table 3 Stratified analyses of 4 different genes’ common polymorphisms on myopia risk.
| Variables | N | Case/Control | M-allele vs W-allele | MW vs WW | MM vs WW | MM+MW vs WW | MM vs MW+WW |
|---|---|---|---|---|---|---|---|
| OR (95% CI)/Ph/P/Bon/I-squared | OR(95% CI Ph/P/Bon/I-squared | OR(95% CI)/Ph/P/Bon/I-squared | OR (95% CI)/Ph/P/Bon/I-squared | OR (95% CI)/Ph/P/Bon/I-squared | |||
| rs634990 | |||||||
| Total | 2 | 476/386 | 0.68 (0.34–1.34)/0.001/0.309/1/91.5% | 1.02 (0.73–1.44)/0.338/0.888/1/0.0% | 0.46 (0.10–2.08)/0.001/0.314/1/91.0% | 0.76 (0.35–1.63)/0.045/0.479/1/75.1% | 0.48 (0.14–1.66)/0.000/0.248/1/92.3% |
| rs3743123 | |||||||
| Total | 3 | 1022/1022 | 0.78 (0.67–0.91)/0.740/0.002/0.010/0.0% | 0.72 (0.60–0.87)/0.555/0.001/0.005/0.0% | 0.76 (0.32–1.81)/0.060/0.539/1/64.4% | 0.73 (0.61–0.87)/0.814/0.000/0.000/0.0% | 0.85 (0.35–2.10)/0.045/0.726/1/67.7% |
| rs4373767 | |||||||
| Total | 4 | 1716/1572 | 0.90 (0.81–1.01/) 0.405/0.067/1/0.0% | 0.84 (0.72–0.98)/0.270/0.027/0.135/23.2% | 0.87 (0.69–1.10)/0.530/0.243/1/0.0% | 0.85 (0.73–0.98)/0.239/0.026/0.130/28.8% | 0.96 (0.77–1.18)/0.883/0.681/1/0.0% |
| rs4428898 | |||||||
| Total | 3 | 1481/1314 | 0.87 (0.77–0.98)/0.294/0.019/0.095/18.2% | 0.82 (0.69–0.97)/0.210/0.019/0.095/36.0% | 0.79 (0.61–1.03)/0.345/0.079/1/6.1% | 0.82 (0.69–0.96)/0.159/0.012/0.060/45.6% | 0.88 (0.69–1.13)/0.763/0.326/1/0.0% |
| rs10779363 | |||||||
| Total | 3 | 2043/1379 | 0.89 (0.80–1.00)/0.291/0.052/1/19.1% | 0.80 (0.68–0.94)/0.256/0.007/0.035/26.5% | 0.88 (0.68–1.15)/0.202/0.358/1/37.5% | 0.82 (0.71–0.96)/0.196/0.011/0.055/38.6% | 0.99 (0.78–1.27)/0.408/0.953/1/0.0% |
| rs7544369 | |||||||
| Total | 3 | 1474/1329 | 0.86 (0.76–0.97)/0.306/0.015/0.075/15.5% | 0.81 (0.68–0.96)/0.371/0.013/0.065/0.0% | 0.79 (0.60–1.04)/0.199/0.091/1/38.2% | 0.81 (0.69–0.95)/0.277/0.009/0.045/22.2% | 0.88 (0.68–1.13)/0.341/0.371/1/7.0% |
| rs1799750 | |||||||
| Total | 2 | 1018/685 | 1.00 (0.86–1.16)/0.816/0.982/1/0.0% | 1.08 (0.88–1.33)/0.821/0.451/1/0.0% | 0.92 (0.67–1.27)/0.719/0.623/1/0.0% | 1.05 (0.86–1.27)/0.969/0.642/1/0.0% | 0.89 (0.65–1.20)/0.638/0.436/1/0.0% |
| rs17576 | |||||||
| Total | 2 | 412/254 | 1.01 (0.78–1.30)/0.541/0.950/1/0.0% | 1.04 (0.74–1.45)/0.600/0.822/1/0.0% | 0.95 (0.47–1.91)/0.630/0.876/1/0.0% | 1.03 (0.75–1.42)/0.552/0.863/1/0.0% | 0.93 (0.47–1.85)/0.701/0.839/1/0.0% |
| – value of test for heterogeneity test; – test for the statistical significance of the OR; W – wild allele; M – mutant allele; Bon – value in stepdown Bonferroni testing. | |||||||