27 May 2026 : Clinical Research
Long-Term Durability and Dynamics of Anti-S-RBD IgG Response in Healthcare Workers: A Comparative Analysis of Homologous and Heterologous SARS-CoV-2 Vaccination Schedules in a 1-Year Serial Cross-Sectional Study
Çiğdem Demirel
ABDEF 1, Filiz Kibar ABDEFG 1,2*, Gülçin Dağlıoğlu DE 2,3, Salih Çetiner DE 2, Aslıhan Candevir DE 4, Ayşe Seza İnal DE 5, Sevinç Püren Yücel Karakaya CD 6, Özlem Görüroğlu Öztürk DE 2,3, Hatice Hale Gümüş DE 1,2, Tamer Cevat İnal DE 2,3
DOI: 10.12659/MSM.952930
Med Sci Monit 2026; 32:e952930
Table 5 Distribution of anti-S-RBD IgG according to time elapsed after vaccination in vaccine statuses.
| Group | Time (weeks) | n (%) | Median (AU/mL) | 95% CI | P value* | Effect size (ɛ2)** |
|---|---|---|---|---|---|---|
| SSSn=39 | ≤12 | 7 (17.9) | 78.2 | 71.4–85.1 | 0.987 | <0.01 |
| 13–24 | 8 (20.5) | 77.4 | 70.2–84.6 | |||
| 25–48 | 10 (25.6) | 77.1 | 69.8–84.3 | |||
| 49+ | 14 (35.9) | 77.0 | 69.5–84.2 | |||
| BBBn=67 | ≤12 | 7 (10.4) | 124.5 | 118.2–130.8 | 0.002 | 0.38 |
| 13–24 | 26 (38.8) | 115.3a | 109.1–121.5 | |||
| 25–48 | 20 (29.9) | 102.4a | 96.2–108.6 | |||
| 49+ | 14 (20.9) | 92.1,a | 85.8–98.4 | |||
| SSBn=60 | ≤12 | 3 (5.0) | 118.4 | 112.1–124.7 | 0.004 | 0.28 |
| 13–24 | 16 (26.7) | 110.2 | 104.0–116.4 | |||
| 25–48 | 12 (20.0) | 98.5,a | 92.3–104.7 | |||
| 49+ | 29 (48.3) | 89.4,a | 83.2–95.6 | |||
| SSBBn=90 | ≤12 | 13 (14.4) | 135.2 | 128.4–142.1 | 0.002 | 0.35 |
| 13–24 | 21 (23.3) | 122.1 | 115.3–128.9 | |||
| 25–48 | 37 (41.1) | 108.4,a | 101.6–115.2 | |||
| 49+ | 19 (21.1) | 98.4,a | 91.2–105.6 | |||
| SSBBBn=51 | ≤12 | 22 (43.1) | 129.4 | 122.6–136.2 | 0.013 | 0.22 |
| 13–24 | 10 (19.6) | 118.5 | 111.7–125.3 | |||
| 25–48 | 19 (37.3) | 104.2,a | 97.4–111.0 | |||
| 49+ | No data | No data | ||||
| * P value was calculated using the Kruskal-Wallis test. ** Epsilon-squared (ɛ) values of 0.01, 0.06, and 0.14 were interpreted as small, medium, and large effect sizes, respectively. a Statistically significant difference compared to the ≤12 weeks group (P b Statistically significant difference compared to the 13–24 weeks group (P | ||||||