10 July 2026 : Clinical Research
Effect of Low-Dose Vonoprazan on Hepatic Cytochrome P450 Activity By 13C-Aminopyrine Breath Test in Healthy Subjects
Satoru Takahashi ABCDE 1, Mihoko Yamade ABCDF 1*, Takahisa Furuta A 2, Tomohiro Higuchi AB 3, Mikihiro Shimizu CD 4, Keisuke Inagaki B 1, Kiichi Sugiura B 1, Tomoharu Matsuura B 5, Natsuki Ishida
B 1, Takanori Yamada B 6, Moriya Iwaizumi F 5, Yasushi Hamaya B 1, Ken Sugimoto F 1, Satoshi Osawa DF 6,7
DOI: 10.12659/MSM.953332
Med Sci Monit 2026; 32:e953332
Table 1 Characteristics of the subjects enrolled in this study.
| Number of subjects | 19 |
| Age, median (range), years | 24 (19–43) |
| Sex, male/female | 10/9 |
| Height, cm | 165.2 ± 7.2 |
| Body weight, kg | 58.4 ± 9.1 |
| BMI, kg/m | 21.3 ± 2.4 |
| WBC, /μL | 5604 ± 1260 |
| RBC, ×10/μL | 486 ± 38 |
| Hb, g/dL | 14.1 ± 1.1 |
| Plt, ×10/μL | 27.0 ± 5.9 |
| AST, U/L | 20.7 ± 5.8 |
| ALT, U/L | 18.1 ± 9.6 |
| LD, U/L | 179 ± 89 |
| ALP, U/L | 70.4 ± 17.9 |
| T. Bil, mg/dL | 0.77 ± 0.38 |
| BUN, mg/dL | 11.7 ± 2.9 |
| Cre, mg/dL | 0.71 ± 0.11 |
| Data are expressed as mean ± SD. BMI, body mass index; WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; PLT, platelets; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LD, lactate dehydrogenase; ALP, alkaline phosphatase; T.Bil, total bilirubin; BUN, Blood urea nitrogen; Cre, creatinine. | |