10 July 2026 : Clinical Research
Effect of Low-Dose Vonoprazan on Hepatic Cytochrome P450 Activity By 13C-Aminopyrine Breath Test in Healthy Subjects
Satoru Takahashi ABCDE 1, Mihoko Yamade ABCDF 1*, Takahisa Furuta A 2, Tomohiro Higuchi AB 3, Mikihiro Shimizu CD 4, Keisuke Inagaki B 1, Kiichi Sugiura B 1, Tomoharu Matsuura B 5, Natsuki Ishida
B 1, Takanori Yamada B 6, Moriya Iwaizumi F 5, Yasushi Hamaya B 1, Ken Sugimoto F 1, Satoshi Osawa DF 6,7
DOI: 10.12659/MSM.953332
Med Sci Monit 2026; 32:e953332
Table 3 Time course and summary metrics of the 13C-aminopyrine breath test under the control condition.
| Actual value | Adjusted value for baseline | |
|---|---|---|
| DOB, 0 min, %dose/h | −0.41 ± 0.21 | 0 |
| DOB, 15 min, %dose/h | 3.07 ± 2.07 | 3.48 ± 2.10 |
| DOB, 30 min, %dose/h | 5.55 ± 2.52 | 5.96 ± 2.54 |
| DOB, 45 min, %dose/h | 5.47 ± 2.04 | 5.88 ± 2.07 |
| DOB, 60 min, %dose/h | 5.25 ± 1.69 | 5.66 ± 1.71 |
| DOB, 75 min, %dose/h | 5.12 ± 1.59 | 5.53 ± 1.61 |
| DOB, 90 min, %dose/h | 4.95 ± 1.41 | 5.36 ± 1.44 |
| DOB, 105 min, %dose/h | 4.76 ± 1.47 | 5.17 ± 1.49 |
| DOB, 120 min, %dose/h | 4.59 ± 1.44 | 5.00 ± 1.46 |
| DOB, 150 min, %dose/h | 4.24 ± 1.23 | 4.65 ± 1.25 |
| DOB, 180 min, %dose/h | 3.99 ± 1.23 | 4.41 ± 1.26 |
| Maximum value of DOB, %dose/h | 6.05 ± 2.11 | 6.46 ± 2.15 |
| Time to maximum value of DOB, min | 49.74 ± 35.78 | 49.74 ± 35.78 |
| AUC 0–3h of DOB, %dose/h | 13.33 ± 4.26 | 14.57 ± 4.26 |
| DOB, delta-over-baseline; AUC, areas under the curve. Actual values and baseline-adjusted values are presented. Inferential statistical analyses were performed using baseline-adjusted values. | ||