Presence and Impact of Fatigue in Patients With Multiple Sclerosis

07 July 2026 : Clinical Research

Meheroz H. Rabadi

^{ADEF 1,2*}, Kimberly A. Russell^{B 1}, Chao Xu

^{CD 3}

DOI: 10.12659/MSM.953344

Med Sci Monit 2026; 32:e953344

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Table 3 Secondary outcomes in multiple sclerosis patients with fatigue by medication status (mean ± SD or median [Q1, Q3]).

	Total (n =1 34)	No (n = 77)	Yes (n = 57)	P value
Initial EQ-5D	9.00 [8.00, 10.0]	9.00 [7.75, 11.0]	9.00 [8.00, 10.0]	0.591^**
12-month EQ-5D	9.00 [7.50, 10.0]	9.00 [8.00, 10.0]	8.50 [6.25, 10.0]	0.343^**
Change EQ-5D	0 [−1.00, 1.00]	0 [−1.00, 1.00]	0 [−1.00, 1.00]	0.818^**
Initial EQ-VAS	70.0 [55.0, 84.0]	60.0 [50.0, 80.0]	75.0 [65.0, 86.0]	0.018^**
12-month EQ-VAS	67.8 (± 16.2)	67.4 (± 13.1)	68.0 (± 18.7)	0.886
Change EQ-VAS	−1.08 (± 20.0)	3.76 (± 21.3)	−5.77 (± 17.8)	0.068
Initial TFIM	120 [113, 124]	120 [113, 124]	121 [114, 125]	0.404^**
12-month TFIM	119 [106, 123]	116 [106, 123]	120 [109, 123]	0.427^**
Change TFIM	−2.00 [−5.50, 1.00]	−3.00 [−9.00, 0]	−1.00 [−4.00, 3.00]	0.044^**
Initial EDSS	2.00 [1.00, 6.00]	1.50 [1.00, 6.00]	2.00 [1.00, 6.00]	0.484^**
12-month EDSS	6.00 [2.00, 6.50]	6.00 [2.00, 6.50]	6.00 [2.00, 6.00]	0.447^**
Change EDSS	1.00 [0, 2.50]	1.00 [0, 4.00]	1.00 [0, 2.00]	0.810^**
Initial ambulation 2MWT in feet	390 [260, 390]	346 [260, 390]	390 [260, 390]	0.997^**
12-month ambulation 2MWT in feet	363 [180, 461]	330 [133, 438]	410 [260, 470]	0.095^**
Change ambulation 2MWT in feet	0 [−50.0, 60.0]	−15.5 [−60.0, 25.0]	40.0 [−22.5, 113]	0.020^**
^* Fisher exact test due to small cell counts. ^** Wilcoxon rank test due to non-normally distributed data, according to the Shapiro normality test. Abbreviations: EQ-5D, EuroQol 5 Domain; VAS, visual analog scale; EDSS, Expanded Disability Scale Score; TFIM, Total Functional Independence Measure; 2MWT, 2-Meter Walk Test.

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