Brain natriuretic peptide is a reliable indicator of ventilatory abnormalities during cardiopulmonary exercise test in heart failure patients.
Angela Beatrice Scardovi, Renata De Maria, Claudio Coletta, Nadia Aspromonte, Silvia Perna, Tommaso Infusino, Stefano Rosato, Manuela Greggi, Tiziana Di Giacomo, Roberto Ricci, Vincenzo Ceci
Med Sci Monit 2006; 12(5): CR191-195
Available online: 2006-05-01
Background: Whether brain natriuretic peptide (BNP), a neurohormone markerof ventricular dysfunction, correlates with an enhanced ventilatory response (EVR) during cardiopulmonaryexercise test, a well-known predictor of prognosis, in systolic heart failure (HF) is currently unknown.Material/Methods: Resting BNP was measured in 134 consecutive stable outpatients aged 69+/-11 years withmild to moderate HF and LV ejection fraction (LVEF) /=35. Results: LVEF averaged 33+/-7%, BNP 350+/-396 pg/ml, and the VE/VCO[sub]2[/sub] slope 36+/-8. Fifty-sixof 123 patients (45%) had EVR. BNP correlated with VE/VCO[sub]2[/sub] slope (r=0.453; p
Keywords: Exercise Test - methods, Heart Failure - physiopathology, Natriuretic Peptide, Brain - blood, Prognosis, Respiratory Insufficiency - physiopathology, Respiratory Physiological Phenomena