24 April 2008
Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells, platelet lysate and dexamethasone
Christopher J. Centeno, Dan Busse, John Kisiday, Cristin Keohan, Michael M FreemanAm J Case Rep 2008; 9:246-251 :: ID: 855038
Abstract
Background: The purpose of this study was to see if percutaneously injected autologous mesenchymal stem cells, platelet lysate, and dexamethasone could reduce this patient’s knee cartilage defect size.
Case Report: A study patient’s mesenchymal stem cells were obtained from her iliac crest bone marrow, isolated and expanded in culture. They were then injected into her knee along with autologous platelet lysate to enhance growth, and nanogram doses of dexamethasone to promote differentiation to chondrocytes. Pre and post treatment MRI imaging, physical therapy and pain score data were then analyzed.
Conclusions: This patient’s MRI data showed a significant decrease in cartilage defect size. Along with this, her measured physical therapy outcomes and subjective pain and functional status all improved. Autologous mesenchymal stem cell injection, in conjunction with platelet lysate and low-dose dexamethasone are a promising minimally invasive therapy for osteoarthritis of the knee.
Keywords: Osteoarthritis, Cartilage, autologous mesenchymal stem cells, Knee, platelet lysate, Dexamethasone, Regeneration
In Press
19 Mar 2024 : Case report
Excimer Laser Therapy for Pigmented Purpuric Dermatosis: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942853
19 Mar 2024 : Case report
Case Report: Primary Cutaneous Histoplasmosis in an Immunocompetent Patient After Cosmetic Injection of Pla...Am J Case Rep In Press; DOI: 10.12659/AJCR.942660
19 Mar 2024 : Case report
Bilateral Simultaneous Basal Ganglia Hemorrhage: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.943174
19 Mar 2024 : Case report
Medial Hoffa Fracture: A Case Report and Literature Review of Approach and ManagementAm J Case Rep In Press; DOI: 10.12659/AJCR.943136
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250