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16 July 2020: Animal Study

Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation

Yunfeng Sun 12AEG , Honghua Pan 12CD , Shenghui Shen 23ABCF , Zhongni Xia 12BC , Zhongmin Yu 2ABCD , ChengLe Li 12F , Pingping Sun 12DEG* , Chuanwei Xin 12DG*

DOI: 10.12659/MSM.921738

Med Sci Monit 2020; 26:e921738

Figure 1 ASD ameliorated thioacetamide-induced hepatotoxicity and associated hepatic dysfunction in vivo. Graphical representations of the effect of 50 mg/kg ASD on (A) TAA-induced ALT or AST elevation, (B) rat liver weight, and (C) rat body weight. (D) Kaplan-Meier plot of the effect of 50 mg/kg ASD on the rat survival rate. TAA – thioacetamide; ASD – Alisma Shugan Decoction; ALT – alanine transaminase; AST – aspartate transaminase. * p<0.05; ** p<0.01; *** p<0.001.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750