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16 July 2020: Animal Study

Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation

Yunfeng Sun 12AEG , Honghua Pan 12CD , Shenghui Shen 23ABCF , Zhongni Xia 12BC , Zhongmin Yu 2ABCD , ChengLe Li 12F , Pingping Sun 12DEG* , Chuanwei Xin 12DG*

DOI: 10.12659/MSM.921738

Med Sci Monit 2020; 26:e921738

Figure 3 ASD suppressed the expression of α-SMA and production of other fibrogenesis-related genes or cytokine levels in the liver injury model rats. (A) Western blot image and (B) graph showing the effect of ASD on the expression of α-SMA protein in cells from rats with TAA-induced liver injury. Histograms of the effect of ASD on the (C) expression levels of α-SMA, procollagen, ICAM-1, MMP2, MMP9, and MMP13 mRNAs, or (D) TIMP-1, ICAM-1, CXCL7, and CD62L cytokine levels in cells from rats with TAA-induced liver injury. α-tubulin was used as loading and internal control. * p<0.05; ** p<0.01; *** p<0.001.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750