16 July 2020 : Animal Research
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo
Yunfeng Sun12AEG, Honghua Pan12CD, Shenghui Shen23ABCF, Zhongni Xia12BC, Zhongmin Yu2ABCD, ChengLe Li12F, Pingping Sun12DEG, Chuanwei Xin12DG*DOI: 10.12659/MSM.921738
Med Sci Monit 2020; 26:e921738
Figure 3 ASD suppressed the expression of α-SMA and production of other fibrogenesis-related genes or cytokine levels in the liver injury model rats. (A) Western blot image and (B) graph showing the effect of ASD on the expression of α-SMA protein in cells from rats with TAA-induced liver injury. Histograms of the effect of ASD on the (C) expression levels of α-SMA, procollagen, ICAM-1, MMP2, MMP9, and MMP13 mRNAs, or (D) TIMP-1, ICAM-1, CXCL7, and CD62L cytokine levels in cells from rats with TAA-induced liver injury. α-tubulin was used as loading and internal control. * p<0.05; ** p<0.01; *** p<0.001.