16 July 2020>: Animal Study
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling DysregulationYunfeng Sun 12AEG , Honghua Pan 12CD , Shenghui Shen 23ABCF , Zhongni Xia 12BC , Zhongmin Yu 2ABCD , ChengLe Li 12F , Pingping Sun 12DEG* , Chuanwei Xin 12DG*
Med Sci Monit 2020; 26:e921738
Figure 4 ASD ameliorated oxidative stress via modulation of Nrf2/JunD/p65 signaling in rats with TAA-induced liver injury. (A) Representative Western blot images and (B) histograms showing the effect of TAA or TAA+ASD on the expression of nuclear-translocated Nrf2, p65, and JunD in rats with TAA-induced liver injury. Histograms of the effect of TAA or TAA+ASD on the (C) GSH/GSSG ratio, (D) 4-hydroxynonenal, or (E) MDA levels in the liver injury model rats. PCNA was used as nuclear marker and as loading control. PCNA – proliferating cell nuclear antigen; GSH – glutathione; GSSG – glutathione disulfide; MDA – malondialdehyde. * p<0.05; ** p<0.01; *** p<0.001.