16 July 2020 : Animal Research
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo
Yunfeng Sun12AEG, Honghua Pan12CD, Shenghui Shen23ABCF, Zhongni Xia12BC, Zhongmin Yu2ABCD, ChengLe Li12F, Pingping Sun12DEG, Chuanwei Xin12DG*DOI: 10.12659/MSM.921738
Med Sci Monit 2020; 26:e921738
Figure 4 ASD ameliorated oxidative stress via modulation of Nrf2/JunD/p65 signaling in rats with TAA-induced liver injury. (A) Representative Western blot images and (B) histograms showing the effect of TAA or TAA+ASD on the expression of nuclear-translocated Nrf2, p65, and JunD in rats with TAA-induced liver injury. Histograms of the effect of TAA or TAA+ASD on the (C) GSH/GSSG ratio, (D) 4-hydroxynonenal, or (E) MDA levels in the liver injury model rats. PCNA was used as nuclear marker and as loading control. PCNA – proliferating cell nuclear antigen; GSH – glutathione; GSSG – glutathione disulfide; MDA – malondialdehyde. * p<0.05; ** p<0.01; *** p<0.001.