08 August 2020 : Clinical Research
Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach
Jian Li1ABF, Ming Ye1D, Jueming Gao1B, Yeqing Zhang2C, Qiyong Zhu2AG, Weibang Liang3AEFG*DOI: 10.12659/MSM.921849
Med Sci Monit 2020; 26:e921849
Figure 3 Candidate targets identification. YQHXD shared 199 candidate targets with the identified targets for ICH related to the pathological process. The targets that overlapped were identified based on Omicshare and show their roles in various GO (A) and KEGG (B) terms. The significance threshold was set at P≤0.05, and the terms enriched were identified by hypergeometric test. (C) Flow chart showing the process of selecting potential targets. In the cPPI network, hubs with higher degree than the median among all network nodes were extracted. In addition, main hubs (candidate targets) were mined by calculating 5 topological features.