17 June 2020 : Database Analysis
Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer
Jin Zhu1AG, Lu Jin1CEF*, Aili Zhang2BCD, Peng Gao1DF, Guangcheng Dai1BF, Ming Xu1CF, Lijun Xu1AD, Dongrong Yang1AEGDOI: 10.12659/MSM.922346
Med Sci Monit 2020; 26:e922346
Figure 5 The impact of EZH2 and coexpressed genes on the overall survival (OS) of patients with cancer. Increased expression of EZH2 and the five most frequently expressed genes (MCM4, KIAA0101, MKI67, RRM2, and CDC25A) are associated with a lower survival rate in breast cancer, gastric cancer, liver cancer, and lung cancer. In lung cancer, the 15 most commonly expressed genes are also analyzed. Increased expression of nine genes (TOP2A, CCNB2, BUB1, BUB1B, CDK1, CCNB1, TPX2, FANCI, and CENPA) predict a lower overall survival. Tumor suppressor genes, PTEN, RB, and TSLC1, are used as negative controls.