Figure 6 The upregulation of SPP1 was validated in different databases. (A) The expression profiling of SPP1 in various tumor types performed by TIMER according to the TCGA database. The red columns stand for tumor samples and the blue columns stand for normal samples. *** Represents that the P<0.001, and ** represents that the P<0.01. (B) A meta-analysis of SPP1 across 5 analyses in the Oncomine database showed that SPP1 was upregulated in LUAD. (C) Immunohistochemistry results of SPP1 protein expression in LUAD tissue and normal tissue from HPA database. TIMER – Tumor Immune Estimation Resource; TCGA – The Cancer Genome Atlas; HPA – Human Protein Atlas; LUAD – lung adenocarcinoma.