15 September 2020>: Lab/In Vitro Research
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3–Cyclophilin A (CypA) Signaling PathwayXiaobo Zhang ABCDEFG* , Ying Zhu BCDEF , Ying Zhou BCDE , Bingru Fei CDE
Med Sci Monit 2020; 26:e922979
Figure 3 IL-37 reduces inflammation of high glucose-treated podocytes. The expression levels of the inflammatory proteins MCP-1, NLRP3, ASC, and caspase-1 were detected by western blot. ** p<0.01, *** p<0.001 vs. NG; ## p<0.01, ### p<0.001 vs. MA; & p<0.05 vs. HG. NG – normal glucose group (medium with 5.5 mM glucose); MA – mannitol-treated podocytes used as the osmotic pressure control group; HG – high-glucose group (medium with 30 mM glucose).