15 September 2020>: Lab/In Vitro Research
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3–Cyclophilin A (CypA) Signaling Pathway
Xiaobo Zhang ABCDEFG* , Ying Zhu BCDEF , Ying Zhou BCDE , Bingru Fei CDEDOI: 10.12659/MSM.922979
Med Sci Monit 2020; 26:e922979
Figure 4 IL-37 alleviated the apoptosis induced by high-glucose treatment of podocytes. (A) The expression of apoptosis was detected by flow cytometry. (B) Statistical analysis of apoptosis. (C) Western blot was used to detect the expression of apoptosis-related proteins. ** p<0.01, *** p<0.001 vs. NG; ## p<0.01, ### p<0.001 vs. MA; & p<0.05, &&& p<0.001 vs. HG. NG – normal glucose group (medium with 5.5 mM glucose); MA – mannitol-treated podocytes used as the osmotic pressure control group; HG – high-glucose group (medium with 30 mM glucose).