15 September 2020: Lab/In Vitro Research
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3–Cyclophilin A (CypA) Signaling Pathway
Xiaobo Zhang ABCDEFG* , Ying Zhu BCDEF , Ying Zhou BCDE , Bingru Fei CDEDOI: 10.12659/MSM.922979
Med Sci Monit 2020; 26:e922979
Figure 6 Overexpression of STAT3 regulated the expression of downstream CypA in cells treated with IL-37. (A) After overexpression of STAT3, expression levels of STAT3 and CypA were detected by RT-qPCR. (B) After overexpression of STAT3, expression of STAT3 and CypA was detected by western blot. (C) Statistical analysis chart of B. (D) After overexpression of CypA, expression levels of STAT3 and CypA were detected by RT-qPCR. (E) After overexpression of CypA, expression of STAT3 and CypA was detected by western blot. (F) Statistical analysis chart of E. * p<0.05, ** p<0.01, *** p<0.001 vs. Oe-NC. Oe-NC – overexpression-negative control.