15 September 2020>: Lab/In Vitro Research
Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3–Cyclophilin A (CypA) Signaling PathwayXiaobo Zhang ABCDEFG* , Ying Zhu BCDEF , Ying Zhou BCDE , Bingru Fei CDE
Med Sci Monit 2020; 26:e922979
Figure 8 Overexpression of STAT3 and CypA inhibited the IL-37-induced reduction of apoptosis in high glucose-treated podocytes. (A) Apoptosis was detected by flow cytometry. B. Statistical analysis of apoptosis. *** p<0.001 vs. NG; ### p<0.001 vs. HG; &&& p<0.001 vs. HG+IL-37. NG – normal glucose group (medium with 5.5 mM glucose); HG – high-glucose group (medium with 30 mM glucose); HG+IL-37 – high-glucose group with added IL-37.