01 September 2020>: Animal Study
Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice
Feilin Dong ABE , Jun Tan CDE , Yi Zheng DF*DOI: 10.12659/MSM.923358
Med Sci Monit 2020; 26:e923358
Figure 1 Chlorogenic acid (CGA) relieved the symptom of allergic rhinitis (AR) induced by ovalbumin (OVA) in mice. (A) The chemical formula of CGA is shown in the figure. (B) The mice were sensitized on days 0, 7, and 14 by OVA and Al(OH)3, and then orally gavaged from day 15 to 25 (11 days) with CAG (50, 100, and 200 mg/kg), Cromolyn disodium salt hydrate (DSGC, 100 mg/kg), or isopycnic distilled water once a day. Next, the mice were challenged with saline containing 10% OVA via nose drops 30 minutes (min) after gavage. Before sacrifice on day 26, (C, D), nasal-rubbing and -sneezing frequencies of the mice in different groups were counted on day 25. n=10 per group. ### P<0.001 vs. control, *** P<0.001 vs. OVA.