01 September 2020>: Animal Study
Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice
Feilin Dong ABE , Jun Tan CDE , Yi Zheng DF*DOI: 10.12659/MSM.923358
Med Sci Monit 2020; 26:e923358
Figure 3 Chlorogenic acid (CGA) reduced mucosa thickness and mucus secretions in the nasal mucosa of mice. (A) Histological features of the nasal mucosa were identified by hematoxylin-eosin (HE) staining, and the mucosa thickness of nasal septum was measured. Enzyme-linked immunosorbent assays (ELISA) were performed to detect the levels of anti-OVA specific IgE (B), anti-OVA IgG1 (C) and anti-OVA IgG2a (D) in the serum of the mice. Scale bar: 10μm, ×1000 magnification. n=10 each group. ### P<0.001 vs. control, * P<0.05, ** P<0.01, *** P<0.001 vs. OVA.