Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang; Yuntao Gu; Hai Zhao; Rong Chen; Wensheng Chen; Hao Qi; Weisong Gao

doi:10.12659/MSM.923386

25 August 2020: Lab/In Vitro Research

Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang ^DEF , Yuntao Gu ^BE , Hai Zhao ^CEF , Rong Chen ^BD , Wensheng Chen ^BF , Hao Qi ^BE , Weisong Gao ^ABG*

DOI: 10.12659/MSM.923386

Med Sci Monit 2020; 26:e923386

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Figure 2 Effects of dioscin on IL-1β-activated cell viability in human NP cells. (A) The cytotoxic effects of dioscin on human NP cells were examined at different concentrations by the CCK-8 method. (B) CCK-8 analysis of dioscin-treated human NP cells stimulated by IL-1β. The results are presented as the means ±SD. * P<0.05 relative to the control group; # P<0.05 relative to the IL-1β group, n=5.

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Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

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