Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang; Yuntao Gu; Hai Zhao; Rong Chen; Wensheng Chen; Hao Qi; Weisong Gao

doi:10.12659/MSM.923386

25 August 2020 : Clinical Research

Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang^1DEF, Yuntao Gu^1BE, Hai Zhao^1CEF, Rong Chen^1BD, Wensheng Chen^1BF, Hao Qi^1BE, Weisong Gao^1ABG*

DOI: 10.12659/MSM.923386

Med Sci Monit 2020; 26:e923386

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Figure 4 Dioscin suppressed IL-1β-activated catabolic activity in human NP cells. (A–D) Relative mRNA level of (A, B) ADAMTS4 and ADAMTS5, and (C, D) MMP3, MMP13 were measured by PCR. The results are presented as the means ±SD. * P<0.05 relative to the control group; # P<0.05 relative to the IL-1β group, n=5.

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Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

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