Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang; Yuntao Gu; Hai Zhao; Rong Chen; Wensheng Chen; Hao Qi; Weisong Gao

doi:10.12659/MSM.923386

25 August 2020 : Clinical Research

Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

Longhui Wang^1DEF, Yuntao Gu^1BE, Hai Zhao^1CEF, Rong Chen^1BD, Wensheng Chen^1BF, Hao Qi^1BE, Weisong Gao^1ABG*

DOI: 10.12659/MSM.923386

Med Sci Monit 2020; 26:e923386

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Figure 5 Dioscin attenuated ECM degradation in IL-1β-stimulated human NP cells. (A, B) Relative mRNA level of (A) collagen II and (B) aggrecan were examined by PCR. (C) Fluorescence immunostaining of collagen II protein (green) and nucleus (blue). The results are presented as the means ±SD. * P<0.05 relative to the control group; # P<0.05 relative to the IL-1β group, n=5.

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Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells

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