25 August 2020>: Lab/In Vitro Research
Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells
Longhui Wang DEF , Yuntao Gu BE , Hai Zhao CEF , Rong Chen BD , Wensheng Chen BF , Hao Qi BE , Weisong Gao ABG*DOI: 10.12659/MSM.923386
Med Sci Monit 2020; 26:e923386
Figure 5 Dioscin attenuated ECM degradation in IL-1β-stimulated human NP cells. (A, B) Relative mRNA level of (A) collagen II and (B) aggrecan were examined by PCR. (C) Fluorescence immunostaining of collagen II protein (green) and nucleus (blue). The results are presented as the means ±SD. * P<0.05 relative to the control group; # P<0.05 relative to the IL-1β group, n=5.