25 August 2020>: Lab/In Vitro Research
Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells
Longhui Wang DEF , Yuntao Gu BE , Hai Zhao CEF , Rong Chen BD , Wensheng Chen BF , Hao Qi BE , Weisong Gao ABG*DOI: 10.12659/MSM.923386
Med Sci Monit 2020; 26:e923386
Figure 6 Dioscin suppressed IL-1β-induced release of proinflammatory factors via regulation of the NF-κB pathway in human NP cells. (A, B) Relative mRNA level of (A) IL-6 and (B) TNF-α were examined by PCR. (C–F) Western blotting and quantitative analysis of TLR4, p65, and IκBα. The results are presented as the means ±SD. * P<0.05 relative to the control group; # P<0.05 relative to the IL-1β group, n=5.