14 July 2020>: Clinical Research
Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling
Binbin Wang 1ABCE* , Qiang Ye 2BCD* , Chuantao Zou 1AEG*DOI: 10.12659/MSM.923507
Med Sci Monit 2020; 26:e923507
Figure 5 THOR regulates TNBC cell stemness dependent on β-catenin expression. (A, B) β-catenin mRNA and protein levels were determined in TNBC cells with THOR knockdown or not, as well as β-catenin overexpression. (C–F) The analysis on the expression of stemness markers in the cells denoted in (B). (G) ALDH1 activity was assessed in the cells denoted in (B). (H, I) The determination on sphere-formation ability in the cells denoted in (B). ** P<0.01. TNBC – triple negative breast cancer; mRNA – messenger RNA.